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ArteFill is a permanent filler that combines bovine (cow) collagen and polymethylmethacrylate microspheres. (PMMA, as it's known, is an acrylic material that has been used in implants for a long time and is known to be easily tolerated by the body.)

The proportion is approximately 80 percent collagen to 20 percent PMMA, along with lidocaine, an anesthetic that makes the procedure more comfortable.

ArteFill is termed a permanent filler because while the collagen is reasborbed into the body over time, the PMMA microspheres remain in the body forever.