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Sculptra Aesthetic is an injectable filler that stimulates collagen growth.

Is Sculptra safer than Restylane for filling?

Nelson Novick (New York, NY) on Sep 21, 2011
Both products are FDA-approved for use in humans. However, each has a different purpose. Restylane is a filling agent and Sculptra is a volumizing material, i.e. an injectable whose purpose is not simply to elevate superficial wrinkles and folds, but to contour and reshape the face by providing volume. Fillers used to volumize tend not to give the appropriate amount of correction, need to be given in large amounts, and tend not to last very long. Volumizers used to treat superficial wrinkles can lead to lumps, bumps and overcorrection. An experienced esthetic physician knows when and where to use each type of product to tailor the treatments to the patient's individual needs. I prefer volumizers, such as Radiesse, to Sculptra, since the latter typically requires several treatment sessions to achieve the desired effect, whereas the results of Radiesse tend to be more immediate.
John Obi (Jacksonville, FL) on Oct 23, 2011
There is no evidence that I am aware of that Sculptra (R) would be any safer that Restylane (R). The use of Sculptra (R) usually requires a series of injections several weeks apart and as such may expose the patient to the risks of injections (bruising, bleeding, infection) more than a single injection of other fillers that are available. Also, Restylane(R) can be used more superficially in the tissues than Sculptra(R), which is usually injected into the deeper tissues.
Robert Strimling (Las Vegas, NV) on Oct 23, 2011
Both are safe. But, Restylane is safer because it can be completely and rapidly reversed with hyaluronidase. However, these two fillers are used for different purposes.