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Restylane is a popular hyaluronic acid-based dermal filler.

By Zeel Editorial Staff, Last updated: April 19, 2018

Treatment Basics

Regulatory approval: Approved by the FDA in December 2003.

Manufacturer: Q Med of Sweden, Medicis

Restylane is a very popular injectable based on hyaluronic acid, used for erasing wrinkles and adding fullness to sagging areas of the face. Hyaluronic acid is a natural substance that already exists in the body; it binds molecules together, helping to firm the skin.

What It's Good For

Areas most commonly treated with Restylane include the lips, the forehead, the nasolabial folds and the undereye area. Restylane can also be used for plumping up cheeks (for the trendy "baby fat" look popularized by Madonna). It can also be used to add definition to the vermilion border and cupid's bow of the lips.

Recommended Uses
Name Description Cost
Acne scars Restylane is a popular hyaluronic acid based dermal filler that is safe for filling up depressed acne scars. Restylane injections cost $500 - $1,000 per syringe and last six months to a year. If you only have a few deep pitted or valley scars, it’s possible that a smaller syringe...more
Crow's feet Restylane is used as a filler to fill in and smooth crow’s feet just below the surface, normally in conjunction with a muscle relaxant like Botox or Dysport. Restylane is a hyaluronic...more Typically one larger syringe of Restylane is used to treat crow’s feet, which will cost...more
Dark circles under eyes Restylane, a temporary hyaluronic-acid based filler, is an effective filler for volume loss in the undereye area. Hyaluronic acid is a sugar-based gel naturally found in human skin. On...more One syringeful will cost between $400 and $700. One or two syringes are usually enough to...more
Downturned mouth Restylane is a good treatment for downturned lips. Restylane is made from hyaluronic acid, a substance that occurs naturally in the skin. A thinning of the lower lip can caused a...more A carefully placed injection of Restylane can improve the appearance of downturned lips. ...more
Glabellar lines (frown lines) Restylane, a hyaluronic acid-based filler, is a good second-line treatment for glabellar lines. It’s not appropriate as the only treatment for these deep, motion-caused wrinkles, but it is...more The 1 cc syringe of Restylane, which would typically be used for glabellar lines, will...more
Horizontal forehead wrinkles Restylane is a good all-around filler and is suitable for deep forehead wrinkles. It lasts about six months in the forehead. It is normally an adjunct to Botox or Dysport treatment to relax...more Treatment of forehead wrinkles with Restylane will cost between $400 and $800 for a full syringe.
Lip wrinkles ("smoker's mouth" or "lipstick lines") Restylane is one of the most popular fillers used to treat lipstick lines. It is a hyaluronic acid-based gel that is harmlessly reabsorbed into the body after six to nine months. One...more The wrinkles on the upper lip, also known as lipstick or smoker’s lines, respond very well...more
Marionette Lines Restylane is a good treatment for moderate to deep marionette lines. It is composed of hyaluronic acid, which does not cause allergic reactions. The soft, colorless nature of the filler...more A single syringe costs $300 to $800.
Nasolabial folds (smile lines) Nasolabial folds are perfectly suited to treatment with Restylane. Restylane is a good all-arounder in the world of fillers. It is a “soft” filler that will not cause a hard, stretched...more One to two syringes of Restylane will be required, costing between $800 and $1,600 (for two...more
Sunken eyes Restylane is one of the best treatments for filling a deep tear trough, an indentation around the eye that can make eyes look sunken. Some feel that Restylane is better-suited to use under...more For less severe cases, a small syringe can be used, which will cost between $300 and $450. ...more
Thinning lips Restylane, a hyaluronic-acid based filler, is one of the more popular fillers for the lips. It is a temporary filler. On average, an injection of Restylane will last six to nine months. ...more The amount of Restylane used to reinflate thinning lips depends on your goals. A small...more
Wrinkles Restylane is good hyaluronic acid filler for moderate to deep wrinkles. Restylane treats crow's feet, nasolabial folds, marionette lines, and horizontal forehead grooves. It cannot be used...more A single syringe of Restylane costs between $500 and $1,000.

Who it works for: Restylane is ideal for treating fine furrows and folds, not deep creases and skin depressions. Restylane may be better suited for fair skinned individuals.

Recommended age range: Restylane shouldn't be used by people under the age of 18.

When will I see results?: Results of Restylane injections are typically immediate, but full results aren't evident until two weeks later, when temporary swelling or bruising has subsided.

How long it lasts: The results of your Restylane injections can last up to 12 months. It starts to break down sooner in the lips and around the mouth, however - expect only up to six months of fill power.

Key benefits of Restylane: Restylane is very popular - and effective for - moderate and deep wrinkles like nasolabial folds, marionette lines, and chin and jowl depressions. Because Restylane does not contain animal products, you won't need a skin test before treatment. Some physicians feel that Restylane attracts less water than Juvederm, making it swell less for some patients immediately after injection.

Licensed uses: Restylane is approved by the FDA for wrinkle reduction. It was the first HA filler approved by the FDA, in 2003.

Who's Done It?

In 2006, Jessica Simpson admitted to Glamour magazine that she used Restylane to get her exaggerated pout. "I had that Restylane stuff. It looked fake to me. I didn't like that. But it went away in, like, four months. My lips are back to what they were. Thank God!"

Lisa Rinna is rumored (with good reason) to have used various lip fillers. She highlights these beauty tricks for her lips in her book, Rinnavation.

Find experts who offer Restylane near you