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Perlane is a long-lasting hyaluronic acid-based filler effective for deep lines and wrinkles.

By Zeel Editorial Staff, Last updated: June 26, 2012

Treatment Basics

Regulatory approval: Approved by the FDA in May 2007.

Manufacturer: Q Med of Sweden, Medicis

A hyaluronic acid dermal filler, Perlane has larger molecules than other HA fillers like Restylane and Juvederm, which makes it especially well-suited to very deep facial wrinkles and folds. Hyaluronic acid is a naturally occurring compound found in human skin, so most people are not allergic to it.

Perlane is manufactured by Medicis, the same company that makes Restylane; Perlane is designed to be injected deeper into the skin than Restylane.

What It's Good For

Perlane addresses facial wrinkles, fine lines, nasolabial folds, and sunken cheeks. The HA filler can enhance your lips by adding definition to the border. Perlane may also soften acne scars.

Recommended Uses
Name Description Cost
Acne scars Perlane is a good filler for depressed acne scars, like boxcar and valley scars. Unless scarring is very extensive, one syringe of Perlane should be enough to fill scarring. Perlane costs $500 to $900 per syringe and lasts approximately nine months.
Horizontal forehead wrinkles Perlane is thicker than other HA fillers like Restylane and Juvederm, making it well-suited for treating forehead wrinkles that are deep and static (that is, they’re present when your face...more One to two syringes of Perlane, at a total cost of $800 to $1800, may be needed for forehead...more
Marionette Lines Marionette lines can readily be plumped by the thick filler Perlane. Results of Perlane injections are immediate and continue to improve gradually. It lasts about six months in marionette...more One or two Perlane syringes ($500 to $900 each) are used to fill marionette lines.
Nasolabial folds (smile lines) Perlane is an effective treatment for moderately deep - or very deep – nasolabial folds, because it has slightly larger molecules than other hyaluronic acid fillers. It is available in a...more Perlane costs between $500 and $800 for a 1cc syringe and is available with added lidocaine....more
Thinning lips Perlane is less commonly used in the lips than Juvederm and Restylane. Because it is thicker, it’s likely to produce a less subtle result. Perlane costs $500 to $900 per syringe.
Wrinkles The molecules in Perlane, a hyaluronic acid filler, are slightly larger than others of its class. For this reason, Perlane is a good treatment for deep nasolabial folds and marionette lines. ...more Each syringe costs $500 to $900—one syringe is usually enough for patients in their 30s.

Who it works for: Whereas Restylane is often used for finer lines and thinner skin, Perlane is effective for deeper lines and wrinkles. It can also plump larger areas of skin and last up to three times as long.

Recommended age range: Perlane (and all hyaluronic acid fillers) shouldn't be used by people under the age of 18.

When will I see results?: Perlane is a filler, so you'll see some results immediately. Because Perlane is injected into deeper layers of skin, it increases collagen production as well. Because increased collagen causes additional plumping, the final results of Perlane injections may take up to six months.

How long it lasts: Perlane breaks down most quickly in the lips - you will need touchups every four to six months. Elsewhere in the face, Perlane lasts for up to nine months.

Key benefits of Perlane: You don't need to be tested for allergies before Perlane injections. It's the best hyaluronic filler if you need substantial filling power. If Perlane is misplaced or becomes lumpy, it can be safely dissolved with an injection of hyaluronase.

Licensed uses: Perlane was approved in May 2007 as a gel implant to add volume to facial tissues. It can smooth wrinkles and folds around the nose and mouth. Your nasolabial folds may thank you.

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