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Dermal fillers

Dermal fillers are one of the most widely used treatments for wrinkles.

By Zeel Editorial Staff, Last updated: May 18, 2020

As the skin ages and is subjected to wear, tear and sun, it falls into disrepair. Production of the three major components of healthy skin— collagen, elastin and hyaluronic acid—slows. Collagen is the support system for the skin. Hyaluronic acid helps the skin hold on to moisture. Elastin helps the skin remain elastic and firm. The skin wrinkles and folds. The lips, which are plumped by collagen, thin as well.

Dermal fillers are one of the most widely used treatments for wrinkles, depressed scars and volume loss in the face and body. They are injected just below the top level of the skin, the epidermis.

There are several different types of dermal fillers, distinguished by the material they are made from. Some dermal fillers are made from components that occur naturally in the skin, like collagen and hyaluronic acid. Others are made with artificial substances like poly-l-lactic acid, silicon and PMMA. Another type of filler is autologic -- that is, it is taken from your own body. Most autologic fillers are made from your fat, though Selphyl, a new autologic filler, uses blood.

Hyaluronic Acid Fillers Hyaluronic acid can be injected into the body to plump the skin and smooth out wrinkles.
Treatment Description Cost
Belotero Belotero is created using a process called Cohesive Polydensified Matrix (CPM) technology. In plain terms, this technique reduces the likelihood of lumps and makes the results last longer. ...more Belotero costs in the ballpark of $400 to $500 per treatment.
Captique Captique is one of a number of dermal fillers made from hyaluronic acid gel currently on the market. Hyaluronic acid, a naturally occurring compound present in our skin, is crucial for supple...more $600-$800 per vial. A typical treatment will use 1-2 vials.
Hylaform Hylaform is a dermal filler made from hyaluronic acid, the all-important compound which makes up much of the skin's structure. When injected into the skin, the hyaluronic acid forms a soft...more At $400-$600 per syringe, Hylaform costs a bit less than most other Hyaluronic acid...more
Juvederm Juvederm is one of the most popular facial fillers. It's largely composed of hyaluronic acid, a substance that occurs naturally in the skin. Juvederm is available in two different strengths:...more Juvederm is typically priced per syringe. The unused portion of a syringe can be stored for...more
Perlane A hyaluronic acid dermal filler, Perlane has larger molecules than other HA fillers like Restylane and Juvederm, which makes it especially well-suited to very deep facial wrinkles and folds. ...more Perlane costs $500 to $900 per syringe. It tends to cost a bit more than...more
Prevelle Silk Prevelle Silk is often thought of as a "starter" filler. Based on hyaluronic acid (HA) gel, Prevelle is slightly thinner and has a lower concentration of HA than other popular fillers like more Prevelle Silk is sold in 1.0 cc syringes. Like all HA fillers, it cannot be stored after...more
Restylane Restylane is a very popular injectable based on hyaluronic acid, used for erasing wrinkles and adding fullness to sagging areas of the face. Hyaluronic acid is a natural substance that...more Restylane is a commonly used hyaluronic acid based filler. It comes in...more

Silicone Injections Silicone is a manmade injectable filler that can be used to augment body parts and to fill wrinkles, facial depressions, and acne scars.
Treatment Description Cost
Silikon 1000 There are many dermal fillers that promise to whisk away wrinkles and plump your puny pout, but few have permanent results. Silikon 1000 is a medical grade silicone oil used to permanently...more Silikon 1000 is injected into lips, cheek hollows, wrinkles, acne...more

Hydroxylapatite Fillers Radiesse, a popular long-lasting filler, makes use of hydroxylapatite, a calcium-rich compound.
Treatment Description Cost
Radiesse Radiesse is a semi-solid implant injected into the skin via needle to fill unwanted wrinkles and lines around the nose and mouth. The artificial substance is made of a calcium-rich compound...more Radiesse is sold in two different sizes - a 0.8 cc syringe and a 1.5 cc...more

Synthetic Poly-L-Lactic Acid Fillers Sculptra is a long-lasting filler composed of a synthetic substance called poly-l-lactic-acid.
Treatment Description Cost
Sculptra Sculptra Aesthetic is an injectable filler that stimulates collagen growth. Sometimes called a "liquid face lift," Sculptra Aesthetic is made from poly-l-lactic acid. Sculptra replaces lost...more Sculptra is generally sold and priced by vial. The amount of Sculptra...more

Collagen Injections A popular cosmetic treatment for many years, collagen fillers are being phased out in favor of hyaluronic acid fillers.
Treatment Description Cost
ArteFill ArteFill is a permanent filler that combines bovine (cow) collagen and polymethylmethacrylate microspheres. (PMMA, as it's known, is an acrylic material that has been used in implants for a...more ArteFill is priced per syringe. It is typically available in an 0.8 cc...more
CosmoDerm CosmoDerm is an injectable filler containing collagen. Specifically, CosmoDerm uses collagen derived from lab-grown human cells, making it different from bovine-based collagen treatments,...more Because CosmoDerm is engineered in a lab from human cells, the injections are expensive to...more
CosmoPlast CosmoPlast is an injectable filler containing collagen. CosmoPlast targets age-related wrinkles, lips that are lacking definition, and noses with bumps or drooping tips. It can add definition...more Human collagen is notably expensive to produce. A single syringe can cost $400 - $700. But...more
Evolence Evolence is a collagen filler derived from pigs. Collagen from pig tendons is collected, purified, and suspended in a saline solution at 3.5%. Pig collagen is similar enough to human...more When it was available, Evolence ran about $700 per syringe. Doctors have noted that it took...more

Autologous Fillers Autologous fillers make use of the body's own material (like fat or blood) to plump up injected areas.
Treatment Description Cost
Fat transfer (injection) Yes, those unwanted adipose deposits on your stomach and rear end can be put to good use - plumping up your cheeks and filling up facial lines with autologous fat injections. (Autologous...more For facial autologous fat injections, the cost usually falls between $1,500 and $4,000 but...more
Selphyl Selphyl, the so-called "vampire facelift"—in which a patient's own blood is injected into the face to stimulate collagen growth—is growing in popularity. Selphyl is an injectable filler which...more Selphyl is not inexpensive. A typical treatment is about $1,200 for four cubic centimeters.

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